Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions

Osama El-Sepelgy, Nurtalya Alandini, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

A dual catalytic iron/lipase system has been developed and applied in the dynamic kinetic resolution of benzylic and aliphatic secondary alcohols. A detailed study of the Knölker-type iron complexes demonstrated the hydrogen autotransfer of alcohols to proceed under mild reaction conditions and allowed the combination with the enzymatic resolution. Different racemic alcohols were efficiently converted to chiral acetates in good yields and with excellent enantioselectivities. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Original languageEnglish (US)
Pages (from-to)13602-13605
Number of pages4
JournalAngewandte Chemie International Edition
Volume55
Issue number43
DOIs
StatePublished - Sep 29 2016

Fingerprint Dive into the research topics of 'Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions'. Together they form a unique fingerprint.

Cite this