Mending a Faltering Heart

Mo Li, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

More people die every year from ischemic heart disease than any other disease. Because the human heart lacks sufficient ability to replenish the damaged cardiac muscles, extensive research has been devoted toward understanding the homeostatic and regenerative potential of the heart and to develop regenerative therapies for heart disease. Here, we discuss recent advances in the understanding of mechanisms governing heart growth during homeostasis or injury, including those from observational studies in humans and experimental research in animal models of cardiac regeneration. We also discuss how progress in stem cell biology and cellular reprogramming has enabled exciting new strategies for cardiac regeneration.

Original languageEnglish (US)
Pages (from-to)344-351
Number of pages8
JournalCirculation Research
Volume118
Issue number2
DOIs
StatePublished - Jan 22 2016

Keywords

  • cellular reprogramming
  • induced pluripotent stem cells
  • myocardial infarction
  • myocardial ischemia
  • myocytes, cardiac

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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