MAP4K4 associates with BIK1 to regulate plant innate immunity.

Yunhe Jiang; Baoda Han; Huoming Zhang; Kiruthiga Mariappan; Jean Bigeard; Jean Colcombet; Heribert Hirt

doi:10.15252/embr.201947965

MAP4K4 associates with BIK1 to regulate plant innate immunity.

Yunhe Jiang, Baoda Han, Huoming Zhang, Kiruthiga Mariappan, Jean Bigeard, Jean Colcombet, Heribert Hirt

Research output: Contribution to journal › Article › peer-review

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Abstract

To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.

Original language	English (US)
Journal	EMBO reports
Volume	20
Issue number	11
DOIs	https://doi.org/10.15252/embr.201947965
State	Published - Sep 2 2019

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https://repository.kaust.edu.sa/bitstream/10754/656694/1/94767_2_merged_1565680521.pdf

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@article{33153323597546829b39745982744667,

title = "MAP4K4 associates with BIK1 to regulate plant innate immunity.",

abstract = "To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.",

author = "Yunhe Jiang and Baoda Han and Huoming Zhang and Kiruthiga Mariappan and Jean Bigeard and Jean Colcombet and Heribert Hirt",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): BAS/1/1062-01-01, URF/1/2965-01-01 Acknowledgements: This work was supported by the King Abdullah University of Science and Technology projects BAS/1/1062-01-01 and URF/1/2965-01-01 and the LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS.",

year = "2019",

month = sep,

day = "2",

doi = "10.15252/embr.201947965",

language = "English (US)",

volume = "20",

journal = "EMBO reports",

issn = "1469-221X",

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T1 - MAP4K4 associates with BIK1 to regulate plant innate immunity.

AU - Jiang, Yunhe

AU - Han, Baoda

AU - Zhang, Huoming

AU - Mariappan, Kiruthiga

AU - Bigeard, Jean

AU - Colcombet, Jean

AU - Hirt, Heribert

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): BAS/1/1062-01-01, URF/1/2965-01-01 Acknowledgements: This work was supported by the King Abdullah University of Science and Technology projects BAS/1/1062-01-01 and URF/1/2965-01-01 and the LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS.

PY - 2019/9/2

Y1 - 2019/9/2

N2 - To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.

AB - To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.

UR - http://hdl.handle.net/10754/656694

UR - https://onlinelibrary.wiley.com/doi/abs/10.15252/embr.201947965

UR - http://www.scopus.com/inward/record.url?scp=85071432622&partnerID=8YFLogxK

U2 - 10.15252/embr.201947965

DO - 10.15252/embr.201947965

M3 - Article

C2 - 31475431

VL - 20

JO - EMBO reports

JF - EMBO reports

SN - 1469-221X

IS - 11

ER -

MAP4K4 associates with BIK1 to regulate plant innate immunity.

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