Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia

Maria F. Casula, Erika Conca, Ioanna Bakaimi, Ayyappan Sathya, Maria Elena Materia, Alberto Casu, Andrea Falqui, Elisa Sogne, Teresa Pellegrino, Antonios G. Kanaras

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

A simple, one pot method to synthesize water-dispersible Mn doped iron oxide colloidal clusters constructed of nanoparticles arranged into secondary flower-like structures was developed. This method allows the successful incorporation and homogeneous distribution of Mn within the nanoparticle iron oxide clusters. The formed clusters retain the desired morphological and structural features observed for pure iron oxide clusters, but possess intrinsic magnetic properties that arise from Mn doping. They show distinct performance as imaging contrast agents and excellent characteristics as heating mediators in magnetic fluid hyperthermia. It is expected that the outcomes of this study will open up new avenues for the exploitation of doped magnetic nanoparticle assemblies in biomedicine. © the Owner Societies 2016.
Original languageEnglish (US)
Pages (from-to)16848-16855
Number of pages8
JournalPhys. Chem. Chem. Phys.
Volume18
Issue number25
DOIs
StatePublished - 2016

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