Magnetic/silica nanocomposites as dual-mode contrast agents for combined magnetic resonance imaging and ultrasonography

Maria Ada Malvindi, Antonio Greco, Francesco Conversano, Albert Figuerola, Maurizio Corti, Marco Bonora, Alessandro Lascialfari, Houshang Amiri Doumari, Marco Moscardini, Roberto Cingolani, Giuseppe Gigli, Sergio Casciaro, Teresa Pellegrino, Andrea Ragusa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

A simple and efficient method for synthesizing a range of hybrid nanocomposites based on a core of silica nanospheres (160, 330, and 660 nm in diameter) covered by an outer shell of superparamagnetic nanoparticles, either iron oxide or heterodimeric FePt-iron oxide nanocrystals, is presented. The magnetic and ultrasound characterization of the resulting nanocomposites shows that they have great potential as contrast agents for dual-mode imaging purposes, combining magnetic resonance imaging (MRI) and ultrasonography (US). The synthesis of a range of hybrid nanocomposites based on a core of silica covered by an outer shell of superparamagnetic nanoparticles, either iron oxide or heterodimeric FePt-iron oxide nanocrystals, is presented. The nanocomposites show potential as contrast agents for dual-mode imaging purposes, combining magnetic resonance imaging and ultrasonography.

Original languageEnglish (US)
Pages (from-to)2548-2555
Number of pages8
JournalAdvanced Functional Materials
Volume21
Issue number13
DOIs
StatePublished - Jul 8 2011

Keywords

  • MRI
  • biomedical applications
  • composite materials
  • core-shell nanoparticles
  • magnetic nanoparticles
  • silica
  • ultrasonography

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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