Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads

Nadja C. Bigall, Alberto Curcio, Manuel Pernia Leal, Andrea Falqui, Domenico Palumberi, Riccardo Di Corato, Ennio Albanesi, Roberto Cingolani, Teresa Pellegrino*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.

Original languageEnglish (US)
Pages (from-to)5645-5650
Number of pages6
JournalAdvanced Materials
Volume23
Issue number47
DOIs
StatePublished - Dec 15 2011

Keywords

  • gold nanoparticles
  • magnetic nanobeads
  • pH-responsive materials
  • siRNA delivery
  • superparamagnetic nanocarriers

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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