Magnesium-Catalyzed Hydroboration of Terminal and Internal Alkynes

Marc Magre, Bholanath Maity, Alban Falconnet, Luigi Cavallo, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A magnesium-catalyzed hydroboration of alkynes providing good yields and selectivities for a wide range of terminal and symmetrical and unsymmetrical internal alkynes has been developed. The compatibility with many functional groups makes this magnesium catalyzed procedure attractive for late stage functionalization. Experimental mechanistic investigations and DFT calculations reveal insights into the reaction mechanism of the magnesium catalyzed protocol.
Original languageEnglish (US)
Pages (from-to)7025-7029
Number of pages5
JournalAngewandte Chemie International Edition
Volume58
Issue number21
DOIs
StatePublished - Apr 12 2019

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