Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

K. Poscharny, D.C. Fabry, S. Heddrich, E. Sugiono, M.A. Liauw, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.
Original languageEnglish (US)
Pages (from-to)3171-3175
Number of pages5
JournalTetrahedron
Volume74
Issue number25
DOIs
StatePublished - Apr 7 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-04-23
Acknowledgements: Technical assistance by Cornelia Vermeeren is very gratefully acknowledged. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement No. 617044 (SunCatChem).

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