Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

K. Poscharny, D.C. Fabry, S. Heddrich, E. Sugiono, M.A. Liauw, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.
Original languageEnglish (US)
Pages (from-to)3171-3175
Number of pages5
JournalTetrahedron
Volume74
Issue number25
DOIs
StatePublished - Apr 7 2018

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