Living polypeptides

Thrasyvoulos Aliferis, Hermis Iatrou, Nikolaos Hadjichristidis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

278 Scopus citations

Abstract

Block copolypeptides, which combine the self-assembly of block copolymers and the highly ordered 3D structures of proteins, are potential candidates for novel supramolecular structures and biotech applications, such as biosensors, tissue engineering, and selective drug delivery. The synthesis of model block copolypeptides through living nucleophilic/basic polymerization of α-amino acid N-carboxyanhydrides (NCAs) has been a challenge for more than fifty years, most probably due to traces of impurities in the system. This problem has been overcome, using high vacuum techniques in order to create and maintain the conditions necessary for the living polymerization of NCAs with primary amines. This method is a general one and opens avenues leading to novel, well-defined polypeptides with various architectures.

Original languageEnglish (US)
Pages (from-to)1653-1656
Number of pages4
JournalBiomacromolecules
Volume5
Issue number5
DOIs
StatePublished - Sep 1 2004

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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