Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

Michael R. Reithofer*, Kiat Hwa Chan, Anupama Lakshmanan, Dang Hoang Lam, Archana Mishra, Began Gopalan, Mangesh Joshi, Shu Wang, Charlotte Hauser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

Original languageEnglish (US)
Pages (from-to)625-630
Number of pages6
JournalChemical Science
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2014

ASJC Scopus subject areas

  • Chemistry(all)

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