Labeled acetate as a marker of astrocytic metabolism

Matthias T. Wyss*, Pierre Magistretti, Alfred Buck, Bruno Weber

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Astrocytes have various important roles in brain physiology. To further elucidate the details of astrocytic functions under normal and pathological states, astrocyte-specific measurements are mandatory. For studying brain energy metabolism, the use of the astrocyte-specific energy substrate acetate has proven to be of great value. Since the first applications of labeled acetate for brain studies about 50 years ago, numerous methodologies have been developed and employed in compartment-specific investigations of brain metabolism. Here, we provide an overview of these different methodological approaches and review studies employing acetate labeled with the most commonly used carbon isotopes.

Original languageEnglish (US)
Pages (from-to)1668-1674
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume31
Issue number8
DOIs
StatePublished - Aug 1 2011

Keywords

  • acetate
  • astrocytes
  • brain imaging
  • energy metabolism
  • kinetic modeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

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