Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

György Székely, Marc Schaepertoens, Piers R J Gaffney*, Andrew G. Livingston

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Highly monodisperse, heterobifunctional poly(ethylene glycol) (PEG) was prepared by iterative chain extension of a PEGylated homostar using an octagol (EG8) building block to give MeO-EG24-OH in high purity. The branched structure facilitated purification of intermediates by chromatography, and mono-functionalization of the chain termini. This approach should be extendable to other classes of oligomers.

Original languageEnglish (US)
Pages (from-to)694-697
Number of pages4
JournalPolymer Chemistry
Volume5
Issue number3
DOIs
StatePublished - Feb 7 2014
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Polymers and Plastics
  • Organic Chemistry

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