Is there interaction between gut microbial profile and cardiovascular risk in chronic kidney disease patients?

Amanda F. Barros, Natália A. Borges, Dennis C. Ferreira, Flávia L. Carmo, Alexandre S. Rosado, Denis Fouque, Denise Mafra

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Aim: To evaluate the gut microbial profile in chronic kidney disease (CKD) patients and evaluate the possible relationship with inflammation and cardiovascular risk. Patients & methods: Markers inflammation plasma and bacterial community profile (denaturing gradient gel electrophoresis) were analyzed. Results: The average number of bands was not different in healthy individuals and CKD patients. The number of bands was negatively associated with plasma levels of VCAM-1 in patients. Flavobacteriaceae bacterium and Listeria monocytogenes were found in patients and Lachnospiraceae bacterium and Butyrivibrio crossotus in healthy individuals. Conclusion: Although CKD patients did not present altered gut microbial profile, the sequencing of bands suggested a different microbiota between groups. The result suggests a possible relationship between gut microbiota and cardiovascular risk in CKD patients.
Original languageEnglish (US)
Pages (from-to)517-526
Number of pages10
JournalFuture Microbiology
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

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