Iron catalysed cross-couplings of azetidines-application to the formal synthesis of a pharmacologically active molecule

Dixit Parmar, Lena Henkel, Josef Dib, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a short formal synthesis towards a pharmacologically active molecule was shown. This journal is

Original languageEnglish (US)
Pages (from-to)2111-2113
Number of pages3
JournalChemical Communications
Volume51
Issue number11
DOIs
StatePublished - Feb 7 2015
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

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