Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy.

Aldo Martinez Banderas, Antonio Aires, Marta Quintanilla, Jorge Alberto Holguin Lerma, Claudia Lozano-Pedraza, Francisco J Teran, Julian Moreno Garcia, Jose E. Perez, Boon S. Ooi, Timothy Ravasi, Jasmeen Merzaban, Aitziber L Cortajarena, Jürgen Kosel

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.
Original languageEnglish (US)
Pages (from-to)43976-43988
Number of pages13
JournalACS Applied Materials & Interfaces
Volume11
Issue number47
DOIs
StatePublished - Nov 4 2019

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