Iridium (I)-Catalyzed Enantioselective Hydroarylation of Alkenes via C-H bond Activation: Experiment and Computation.

Magnus Rueping, Valmik Shinde, Manoj Mane, Luigi Cavallo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A new catalytic enantioselective hydroarylation of unactivated olefins provides rapid access to functionalized chiral dihydrobenzofurans with good yields and excellent enantio-selectivities. Simple aromatic ketones or amides act as directing group allowing the regioselective reaction at the more hindered ortho position. Tertiary benzylic stereocenters are obtained directly under mild reaction conditions and with complete atom economy from readily available starting materials.
Original languageEnglish (US)
Pages (from-to)8308-8313
Number of pages6
JournalChemistry (Weinheim an der Bergstrasse, Germany)
Volume26
Issue number37
DOIs
StatePublished - Apr 18 2020

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