Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls

Ghayoor Chotana, Soneela Asghar, Tayyaba Shahzadi, Meshari Alazmi, Xin Gao, Abdul-Hamid M. Emwas, Rahman Saleem, Farhat Batool

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Biarylboronic esters are generally prepared by directed ortho­ -metalation or by Miyaura borylation and hence rely on the presence of a directing group or pre-functionalization. In this paper, the preparation of biarylboronic esters by direct C–H borylation of biaryl substrates is reported. Sterically governed regioselectivities were observed in the borylation of appropriately substituted biaryls by using [Ir(OMe)(COD)] precatalyst and di- tert -butylbipyridyl ligand. The resulting biarylboronic esters were isolated in 38–98% yields. The synthesized biarylboronic esters were further successfully employed in C–O, C–Br, and C–C coupling reactions.
Original languageEnglish (US)
Pages (from-to)2211-2220
Number of pages10
Issue number11
StatePublished - Mar 28 2018


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