IPSC technology to study human aging and aging-related disorders

Guang Hui Liu*, Zhichao Ding, Juan Carlos Izpisua Belmonte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.

Original languageEnglish (US)
Pages (from-to)765-774
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume24
Issue number6
DOIs
StatePublished - Dec 1 2012

ASJC Scopus subject areas

  • Cell Biology

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