Intrinsic function of a neuronal network - A vertebrate central pattern generator

Sten Grillner*, Örjan Ekeberg, Abdeljabbar El Manira, Anders Lansner, David Parker, Jesper Tegner, Peter Wallén

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

203 Scopus citations

Abstract

The cellular bases of vertebrate locomotor behaviour is reviewed using the lamprey as a model system. Forebrain and brainstem cell populations initiate locomotor activity via reticulospinal fibers activating a spinal network comprised of glutamatergic and glycinergic interneurons. The role of different subtypes of Ca2+ channels, Ca2+ dependent K+ channels and voltage dependent NMDA channels at the neuronal and network level is in focus as well as the effects of different metabotropic, aminergic and peptidergic modulators that target these ion channels. This is one of the few vertebrate networks that is understood at a cellular level.

Original languageEnglish (US)
Pages (from-to)184-197
Number of pages14
JournalBrain Research Reviews
Volume26
Issue number2-3
DOIs
StatePublished - May 1 1998

Keywords

  • Glutamate
  • Glycine
  • Ion channels
  • Locomotion
  • Modellin
  • Networks
  • Tachykinin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Intrinsic function of a neuronal network - A vertebrate central pattern generator'. Together they form a unique fingerprint.

Cite this