Intragenic recombinations in rotaviruses

Yoshiyuki Suzuki, Takashi Gojobori*, Osamu Nakagomi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

In this paper, evidence for intragenic recombination in the VP7 gene between rotavirus strains bearing different serotypes is demonstrated for the first time. Intragenic recombination may be one of the escaping mechanisms from the host immune system for rotavirus. This process involves exchanging antigenic regions, thus questioning the use of multivalent vaccines for the prevention of rotavirus infection.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalFEBS Letters
Volume427
Issue number2
DOIs
StatePublished - May 8 1998

Keywords

  • Evolution
  • Intragenic recombination
  • Rotavirus
  • Vaccine

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Intragenic recombinations in rotaviruses'. Together they form a unique fingerprint.

Cite this