Interrelatedness between C-reactive protein and oxidized low-density lipoprotein

M.M. Obradovic, A. Trpkovic, V. Bajic, S. Soskic, A. Jovanovic, J. Stanimirovic, M. Panic, E.R. Isenovic

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

© De Gruyter 2015.C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.
Original languageEnglish (US)
JournalClinical Chemistry and Laboratory Medicine
Volume53
Issue number1
DOIs
StatePublished - 2015

Keywords

  • [C-reactive protein (CRP), C-reactive protein and

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