Interferon-γ: An overview of signals, mechanisms and functions

Kate Schroder, Paul J. Hertzog, Timothy Ravasi, David A. Hume*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2606 Scopus citations

Abstract

Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-γ ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection. The current model for IFN-γ signal transduction is discussed, as well as signal regulation and factors conferring signal specificity. Cellular effects of IFN-γ are described, including up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-α, interleukin-4, type I IFNs, and lipopolysaccharide are discussed.

Original languageEnglish (US)
Pages (from-to)163-189
Number of pages27
JournalJournal of Leukocyte Biology
Volume75
Issue number2
DOIs
StatePublished - Feb 1 2004

Keywords

  • Cytokine
  • Inflammation
  • Lipopolysaccharide
  • Macrophage
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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