Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs

Krystle M. Veerman, Michael J. Williams, Kenji Uchimura, Mark S. Singer, Jasmeen Merzaban, Silvia Naus, Douglas A. Carlow, Philip Owen, Jesús Rivera-Nieves, Steven D. Rosen, Hermann J. Ziltener*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. Here we show that PSGL-1 was also required for efficient homing of resting T cells to secondary lymphoid organs but functioned independently of selectin binding. PSGL-1 mediated an enhanced chemotactic T cell response to the secondary lymphoid organ chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule.

Original languageEnglish (US)
Pages (from-to)532-539
Number of pages8
JournalNature Immunology
Volume8
Issue number5
DOIs
StatePublished - May 1 2007

ASJC Scopus subject areas

  • Immunology

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