Interaction between transforming Theileria parasites and their host bovine leukocytes

Shahin Tajeri, Malak Haidar, Takaya Sakura, Gordon Langsley

Research output: Contribution to journalArticlepeer-review

Abstract

Theileria are tick-transmitted parasites that cause often fatal leuko-proliferative diseases in cattle called tropical theileriosis (T. annulata) and East Coast fever (T. parva). However, upon treatment with anti-theilerial drug-transformed leukocytes die of apoptosis indicating that Theileria-induced transformation is reversible making infected leukocytes a powerful example of how intracellular parasites interact with their hosts. Theileria-transformed leukocytes disseminate throughout infected cattle causing a cancer-like disease and here, we discuss how cytokines, noncoding RNAs and oncometabolites can contribute to the transformed phenotype and disease pathology.
Original languageEnglish (US)
JournalMolecular Microbiology
DOIs
StatePublished - Feb 9 2021

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