Inter-RNA homology and possible roles of small RNAs

Takashi Gojobori, Masatoshi Nei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The nucleotide sequence of a segment of U1 and U3b small RNAs (sRNAs) is shown to have a high complementarity with the nucleotide sequence of a part of the leader region of almost all eukaryotic genes studied so far. The complementary region of U3b is located in the unpaired segment of the secondary structure of U3b constructed by Reddy et al. (1979). A similar complementarity is also observed between these RNAs and the leader regions of eukaryotic viruses, but the complementary region is not always identical with that for eukaryotic genes. Complementarity is also observed between the 3′ end of 18S rRNA and a segment of U1 or U3b which is almost contiguous to the region complementary with mRNA. These observations suggest that U1 and U3b may be involved in mRNA processing and transport in the nucleus or in translation in the cytoplasm. In addition to U1 and U3b, another sRNA, i.e., 4.5S RNAI, is shown to have segments which are homologous to the Hogness box of the flanking region of gene and the Proudfoot-Brownlee (PB) box of mRNA near the poly(A) attachment site. The two segments which are complementary with these boxes are located almost contiguously on a co-joined loop of the secondary structure of 4.5S RNAI constructed by Ro-Choi et al. (1972). Since the Hogness box and PB box are both considered as a recognition site by the RNA polymerase, it is possible that 4.5S RNAI is involved in mediating gene transcription.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalJournal of Molecular Evolution
Volume17
Issue number4
DOIs
StatePublished - Jul 1 1981

Keywords

  • 18S rRNA
  • Sequence homology
  • Small RNAs
  • Transcription
  • mRNA
  • mRNA processing

ASJC Scopus subject areas

  • Genetics(clinical)
  • Molecular Biology
  • Genetics
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)

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