Integration of fractal biosensor in a digital microfluidic platform

Yousof Mashraei, Shilpa Sivashankar, Ulrich Buttner, Khaled N. Salama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Fractal capacitive electrodes have been successfully integrated into a digital microfluidic open-platform. These electrodes perform actuation and withstand voltages up to 300V without insulation-layer breakdown. They were used to quantify the concentration levels of C-reactive protein (CRP) to determine the risk of cardiovascular disease. The capacitance increased sevenfold and stabilized in less than 5 minutes. The sensor shows a decreasing trend of capacitance readouts with the increase of concentrations. The same immunoassay was tested with untreated electrodes and showed no significant response, which suggests that immobilization was necessary. This configuration allows the electrodes to be used as biosensors.
Original languageEnglish (US)
Title of host publication2015 IEEE SENSORS
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
ISBN (Print)9781479982035
DOIs
StatePublished - Jan 7 2016

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