Integrating carbon nanotubes and lipid bilayer for biosensing

Yinxi Huang, Preeti Vikas Palkar, Lain-Jong Li, Hua Zhang, Peng Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Membrane proteins, which are the target of most drugs, are implicated in many critical cellular functions such as signal transduction, bioelectricity, exocytosis and endocytosis. Therefore, developing techniques to investigate the functions of membrane proteins is obviously important. Here, we have developed a novel system by integrating artificial lipid bilayer (biomimetic membrane) with single-walled carbon nanotube networks (SWNT-net) based field-effect transistor (FET), and demonstrated that such hybrid nanoelectronic biosensors can specifically and electronically detect the presence and dynamic activities of ionophores (specifically, gramicidin and calcimycin) in their native lipid environment. This technique can potentially be used to examine other membrane proteins (e.g. ligand-gated ion channels, receptors, membrane insertion toxins, and antibacterial peptides) for the purposes of biosensing, fundamental studies, or high throughput drug screening.

Original languageEnglish (US)
Pages (from-to)1834-1837
Number of pages4
JournalBiosensors and Bioelectronics
Volume25
Issue number7
DOIs
StatePublished - Mar 15 2010

Keywords

  • Bioelectronics
  • Carbon nanotubes
  • Lipid bilayer
  • Membrane proteins

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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