Inorganic Janus particles for biomedical applications

Isabel Schick, Steffen Lorenz, Dominik Gehrig, Stefan Tenzer, Wiebke Storck, Karl Fischer, Dennis Strand, Frederic Laquai, Wolfgang Tremel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Based on recent developments regarding the synthesis and design of Janus nanoparticles, they have attracted increased scientific interest due to their outstanding properties. There are several combinations of multicomponent hetero-nanostructures including either purely organic or inorganic, as well as composite organic-inorganic compounds. Janus particles are interconnected by solid state interfaces and, therefore, are distinguished by two physically or chemically distinct surfaces. They may be, for instance, hydrophilic on one side and hydrophobic on the other, thus, creating giant amphiphiles revealing the endeavor of self-assembly. Novel optical, electronic, magnetic, and superficial properties emerge in inorganic Janus particles from their dimensions and unique morphology at the nanoscale. As a result, inorganic Janus nanoparticles are highly versatile nanomaterials with great potential in different scientific and technological fields. In this paper, we highlight some advances in the synthesis of inorganic Janus nanoparticles, focusing on the heterogeneous nucleation technique and characteristics of the resulting high quality nanoparticles. The properties emphasized in this review range from the monodispersity and size-tunability and, therefore, precise control over size-dependent features, to the biomedical application as theranostic agents. Hence, we show their optical properties based on plasmonic resonance, the two-photon activity, the magnetic properties, as well as their biocompatibility and interaction with human blood serum.

Original languageEnglish (US)
Pages (from-to)2346-2362
Number of pages17
JournalBeilstein Journal of Nanotechnology
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Bioimaging (CT
  • Hetero-nanoparticles
  • Janus particles
  • MRI
  • Multi-photon)
  • Protein corona
  • Synthesis

ASJC Scopus subject areas

  • Materials Science(all)
  • Physics and Astronomy(all)
  • Electrical and Electronic Engineering

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