Inferring biological functions of guanylyl cyclases with computational methods

May Majed Alquraishi, Stuart Kurt Meier

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A number of studies have shown that functionally related genes are often co-expressed and that computational based co-expression analysis can be used to accurately identify functional relationships between genes and by inference, their encoded proteins. Here we describe how a computational based co-expression analysis can be used to link the function of a specific gene of interest to a defined cellular response. Using a worked example we demonstrate how this methodology is used to link the function of the Arabidopsis Wall-Associated Kinase-Like 10 gene, which encodes a functional guanylyl cyclase, to host responses to pathogens. © Springer Science+Business Media New York 2013.
Original languageEnglish (US)
Pages (from-to)225-234
Number of pages10
JournalMethods in Molecular Biology
Volume1016
DOIs
StatePublished - Sep 3 2013

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

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