Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients

Antonio Conti, Nilo Riva, Mariasabina Sabina Pesca, Sandro Iannaccone, Carlo Cannistraci, Massimo Corbo, Stefano Carlo Previtali, Angelo Quattrini, Massimo Alessio

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Amyotrophic lateral sclerosis (ALS) is a severe and fatal neurodegenerative disease of still unknown pathogenesis. Recent findings suggest that the skeletal muscle may play an active pathogenetic role. To investigate ALS's pathogenesis and to seek diagnostic markers, we analyzed skeletal muscle biopsies with the differential expression proteomic approach. We studied skeletal muscle biopsies from healthy controls (CN), sporadic ALS (sALS), motor neuropathies (MN) and myopathies (M). Pre-eminently among several differentially expressed proteins, Myosin binding protein H (MyBP-H) expression in ALS samples was anomalously high. MyBP-H is a component of the thick filaments of the skeletal muscle and has strong affinity for myosin, but its function is still unclear. High MyBP-H expression level was associated with abnormal expression of Rho kinase 2 (ROCK2), LIM domain kinase 1 (LIMK1) and cofilin2, that might affect the actin-myosin interaction. We propose that MyBP-H expression level serves, as a putative biomarker in the skeletal muscle, to discriminate ALS from motor neuropathies, and that it signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of ALS. © 2013 Elsevier B.V.
Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
JournalBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume1842
Issue number1
DOIs
StatePublished - Jan 2014

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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