In vivo measurement of dye concentration using an evanescent-wave optical sensor

P. Poscio*, Y. Emery, P. Bauerfeind, Christian Depeursinge

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A miniaturised evanescent-wave optical sensor is proposed for in vivo measurement of dye concentrations. It enables a continuous monitoring of the optical-dye attenuation or fluorescence spectra between 380 and 650 nm. The sensor is constructed with polished fibres: the cladding of a single-mode fibre is removed by longitudinal polishing. The proximity of the core to the medium favours penetration of the evanescent part of the modal field into the bio fluid. The dimensions of the probe permit several potential applications: for example, insertion into hypodermic needles for spectroscopic analysis of tissues and blood. In the paper, a gastro-enterologic application of the sensor introduced into a catheter is reported. In vivo tests demonstrate the feasibility of quantitative measurement of dye clearance in the gastro-oesophageal tract.

Original languageEnglish (US)
Pages (from-to)362-366
Number of pages5
JournalMedical & Biological Engineering & Computing
Volume32
Issue number4
DOIs
StatePublished - Jul 1 1994

Keywords

  • Clearance
  • Dye tracer
  • Evanescent wave
  • Gastro-esophageal tract
  • Optical sensor

ASJC Scopus subject areas

  • Biomedical Engineering
  • Computer Science Applications

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