In vitro generation of platelets through direct conversion: First report in My Knowledge (iMK)

Shigeo Masuda, Mo Li, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalCell Research
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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