In situ microfluidic biofunctionalisation to form multivalent interactions and investigate cell rolling and phenotype modification

Gerardo Perozziello*, Giuseppina Simone, Rosanna La Rocca, Francesca Pardeo, Patrizio Candeloro, Natalia Malara, Carlo Liberale, Francesco De Angelis, Giovanni Cuda, Ennio Carbone, Enzo Di Fabrizio

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We propose a method to biofunctionalise microfluidic systems for cellomic investigations based on microfluidic protocols. The biofunctionalised devices were used to perform cell rolling and investigate tumor cell phenotype changes. The strong attention to the modification of the environment by biomolecules (antibodies, proteins or carbohydrate and lectins) has encouraged the studies of the cell behaviour in biomimetic environments. The final aim of cell rolling investigations is to give etiological explanation of diseases, pathologies and sudden change in cell behaviour or cell phenotype and genotype.

Original languageEnglish (US)
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1090-1092
Number of pages3
ISBN (Print)9780979806452
StatePublished - Jan 1 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: Oct 28 2012Nov 1 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period10/28/1211/1/12

Keywords

  • Biofunctionalisation
  • Cell rolling
  • Phenotype modifications

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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