Improving your target-template alignment with MODalign.

Alessandro Barbato, Pascal Benkert, Torsten Schwede, Anna Tramontano, Jan Kosinski

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

SUMMARY: MODalign is an interactive web-based tool aimed at helping protein structure modelers to inspect and manually modify the alignment between the sequences of a target protein and of its template(s). It interactively computes, displays and, upon modification of the target-template alignment, updates the multiple sequence alignments of the two protein families, their conservation score, secondary structure and solvent accessibility values, and local quality scores of the implied three-dimensional model(s). Although it has been designed to simplify the target-template alignment step in modeling, it is suitable for all cases where a sequence alignment needs to be inspected in the context of other biological information. AVAILABILITY AND IMPLEMENTATION: Freely available on the web at http://modorama.biocomputing.it/modalign. Website implemented in HTML and JavaScript with all major browsers supported. CONTACT: jan.kosinski@uniroma1.it.
Original languageEnglish (US)
Pages (from-to)1038-1039
Number of pages2
JournalBioinformatics
Volume28
Issue number7
DOIs
StatePublished - Feb 4 2012
Externally publishedYes

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