Improving the Compatibility of Diketopyrrolopyrrole (DPP) Semiconducting Polymers for Biological Interfacing by Lysine Attachment

weiyuan du, David ohayon, Craig Combe, Lorene Mottier, Iuliana P. Maria, Raja Ashraf, Hubert Fiumelli, Sahika Inal, Iain McCulloch

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Organic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged and low surface energy of semiconducting thin films limit their use in in vitro, cell integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole (DPP) semiconducting polymer on neural cell adhesion and growth, as well as evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need of biological coating steps while changing the surface physiochemistry, promising for applications in bioelectronics.
Original languageEnglish (US)
Pages (from-to)6164-6172
Number of pages9
JournalChemistry of Materials
Volume30
Issue number17
DOIs
StatePublished - Aug 17 2018

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