Improving functional modules discovery by enriching interaction networks with gene profiles

Saeed Salem, Rami Alroobi, Shadi Banitaan, Loqmane Seridi, Ibrahim Aljarah, James Brewer

Research output: Contribution to journalArticlepeer-review

Abstract

Recent advances in proteomic and transcriptomic technologies resulted in the accumulation of vast amount of high-throughput data that span multiple biological processes and characteristics in different organisms. Much of the data come in the form of interaction networks and mRNA expression arrays. An important task in systems biology is functional modules discovery where the goal is to uncover well-connected sub-networks (modules). These discovered modules help to unravel the underlying mechanisms of the observed biological processes. While most of the existing module discovery methods use only the interaction data, in this work we propose, CLARM, which discovers biological modules by incorporating gene profiles data with protein-protein interaction networks. We demonstrate the effectiveness of CLARM on Yeast and Human interaction datasets, and gene expression and molecular function profiles. Experiments on these real datasets show that the CLARM approach is competitive to well established functional module discovery methods.
Original languageEnglish (US)
Pages (from-to)328-338
Number of pages11
JournalCurrent Bioinformatics
Volume8
Issue number3
DOIs
StatePublished - May 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Computational Mathematics
  • Molecular Biology

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