Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Jing-Xiang Zhang, Wai-Lun Chan, Chen Xie, Yan Zhou, Ho-Fai Chau, Partha Maity, George T. Harrison, Aram Amassian, Omar F. Mohammed, Peter A. Tanner, Wai-Kwok Wong, Ka-Leung Wong

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (1O2) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates.
Original languageEnglish (US)
JournalLight: Science & Applications
Volume8
Issue number1
DOIs
StatePublished - May 22 2019

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