Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery

Haneen Omar, Basem Moosa, Kholod Alamoudi, Dalaver H. Anjum, Abdul-Hamid M. Emwas, Omar El Tall, Binh Vu, Fuyu Tamanoi, Abdulaziz AlMalik, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Porous materials with molecular-scale ordering have attracted major attention mainly because of the possibility to engineer their pores for selective applications. Periodic mesoporous organosilica is a class of hybrid materials where self-assembly of the organic linkers provides a crystal-like pore wall. However, unlike metal coordination, specific geometries cannot be predicted because of the competitive and dynamic nature of noncovalent interactions. Herein, we study the influence of competing noncovalent interactions in the pore walls on the biodegradation of organosilica frameworks for drug delivery application. These results support the importance of studying self-assembly patterns in hybrid frameworks to better engineer the next generation of dynamic or “soft” porous materials.
Original languageEnglish (US)
Pages (from-to)5195-5201
Number of pages7
JournalACS Omega
Volume3
Issue number5
DOIs
StatePublished - May 14 2018

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