Impact of MCT1 Haploinsufficiency on the Mouse Retina

Neal S. Peachey, Minzhong Yu, John Y. S. Han, Sylvain Lengacher, Pierre J. Magistretti, Luc Pellerin, Nancy J. Philp

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.
Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer International Publishing
Pages375-380
Number of pages6
ISBN (Print)9783319754017
DOIs
StatePublished - May 2 2018

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