Impact of MCT1 Haploinsufficiency on the Mouse Retina

Neal S. Peachey; Minzhong Yu; John Y. S. Han; Sylvain Lengacher; Pierre J. Magistretti; Luc Pellerin; Nancy J. Philp

doi:10.1007/978-3-319-75402-4_46

Impact of MCT1 Haploinsufficiency on the Mouse Retina

Neal S. Peachey, Minzhong Yu, John Y. S. Han, Sylvain Lengacher, Pierre J. Magistretti, Luc Pellerin, Nancy J. Philp

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer International Publishing
Pages	375-380
Number of pages	6
ISBN (Print)	9783319754017
DOIs	https://doi.org/10.1007/978-3-319-75402-4_46
State	Published - May 2 2018

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10.1007/978-3-319-75402-4_46

https://repository.kaust.edu.sa/bitstream/10754/627851/1/Book%20Chapterfile1.pdf

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title = "Impact of MCT1 Haploinsufficiency on the Mouse Retina",

abstract = "The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.",

author = "Peachey, {Neal S.} and Minzhong Yu and Han, {John Y. S.} and Sylvain Lengacher and Magistretti, {Pierre J.} and Luc Pellerin and Philp, {Nancy J.}",

note = "KAUST Repository Item: Exported on 2021-02-19 Acknowledgements: This work was supported by grants from NIH (R01EY12042) and Department of Veterans Affairs (I01BX2340) and by the Foundation Fighting Blindness and Research to Prevent Blindness.",

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doi = "10.1007/978-3-319-75402-4_46",

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T1 - Impact of MCT1 Haploinsufficiency on the Mouse Retina

AU - Peachey, Neal S.

AU - Yu, Minzhong

AU - Han, John Y. S.

AU - Lengacher, Sylvain

AU - Magistretti, Pierre J.

AU - Pellerin, Luc

AU - Philp, Nancy J.

N1 - KAUST Repository Item: Exported on 2021-02-19 Acknowledgements: This work was supported by grants from NIH (R01EY12042) and Department of Veterans Affairs (I01BX2340) and by the Foundation Fighting Blindness and Research to Prevent Blindness.

PY - 2018/5/2

Y1 - 2018/5/2

N2 - The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

AB - The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

UR - http://hdl.handle.net/10754/627851

UR - http://link.springer.com/chapter/10.1007/978-3-319-75402-4_46

UR - http://www.scopus.com/inward/record.url?scp=85046618598&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-75402-4_46

DO - 10.1007/978-3-319-75402-4_46

M3 - Chapter

AN - SCOPUS:85046618598

SN - 9783319754017

SP - 375

EP - 380

BT - Advances in Experimental Medicine and Biology

PB - Springer International Publishing

ER -

Impact of MCT1 Haploinsufficiency on the Mouse Retina

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