Hydrophilic, protein-resistant surface modification of polymer monoliths via photografting for multifunctional microfluidic devices

Timothy B. Stachowiak, Frantisek Svec, Jean M J Fréchet

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

Polymer monoliths that resist the adsorption of proteins were prepared using both single- and two-step photografting of hydrophilic monomers. The adsorption of protein was measured using a fluorescent assay based on bovine serum albumin labeled with fluorescein. By photografting hydrophilic monomers such as poly(ethylene glycol) methacrylate onto polymer monoliths, protein adsorption was reduced by 98% relative to unmodified surfaces.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference
Subtitle of host publication10th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherJapan Academic Association Inc
Pages227-229
Number of pages3
StatePublished - 2006
Externally publishedYes
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: Nov 5 2006Nov 9 2006

Other

Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CountryJapan
CityTokyo
Period11/5/0611/9/06

Keywords

  • Adsorption
  • Photografting
  • Polymer monolith
  • Surface modification

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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