Hydride Transfer Enables the Nickel-Catalyzed ipso-Borylation and Silylation of Aldehydes

Watchara Srimontree, Lin Guo, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Nickel-catalyzed ipso-borylations and silylations of aldehydes are described for the first time. The new functional-group interconversion protocol is characterized by its scalability, functional-group tolerance and wide substrate scope, including examples of late-stage functionalization of complex molecules. The key for the successful reaction outcome is the use of a ketone as a hydride acceptor that intercepts the nickel hydride to undergo a reductive pathway, thus allowing formation of the desired C−B and C−Si bonds.
Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalChemistry - A European Journal
Volume26
Issue number2
DOIs
StatePublished - Dec 9 2019

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