Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice

Timothy K Cooper, Kathleen A Silva, Victoria E Kennedy, Sarah Alghamdi, Robert Hoehndorf, Beth A Sundberg, Paul N Schofield, John P Sundberg

Research output: Contribution to journalArticlepeer-review

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Abstract

During a screen for vascular phenotypes in aged laboratory mice, a unique discrete phenotype of hyaline arteriolosclerosis of the intertubular arteries and arterioles of the testes was identified in several inbred strains. Lesions were limited to the testes and did not occur as part of any renal, systemic, or pulmonary arteriopathy or vasculitis phenotype. There was no evidence of systemic or pulmonary hypertension, and lesions did not occur in ovaries of females. Frequency was highest in males of the SM/J (27/30, 90%) and WSB/EiJ (19/26, 73%) strains, aged 383 to 847 days. Lesions were sporadically present in males from several other inbred strains at a much lower (
Original languageEnglish (US)
Pages (from-to)799-806
Number of pages8
JournalVeterinary Pathology
Volume56
Issue number5
DOIs
StatePublished - May 6 2019

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