Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy

Fei Yi, Guang Hui Liu*, Juan Carlos Izpisua Belmonte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalProtein and Cell
Volume3
Issue number4
DOIs
StatePublished - Jan 1 2012

Keywords

  • cell therapy
  • disease modeling
  • drug development
  • hepatocytes
  • induced pluripotent stem cells

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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