How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions

Katarzyna Wiktoria Walkiewicz, Jean-Antoine Girault, Stefan T. Arold

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The focal adhesion kinase (FAK) and the related protein-tyrosine kinase 2-beta (Pyk2) are highly versatile multidomain scaffolds central to cell adhesion, migration, and survival. Due to their key role in cancer metastasis, understanding and inhibiting their functions are important for the development of targeted therapy. Because FAK and Pyk2 are involved in many different cellular functions, designing drugs with partial and function-specific inhibitory effects would be desirable. Here, we summarise recent progress in understanding the structural mechanism of how the tug-of-war between intramolecular and intermolecular interactions allows these protein ‘nanomachines’ to become activated in a site-specific manner.
Original languageEnglish (US)
Pages (from-to)60-71
Number of pages12
JournalProgress in Biophysics and Molecular Biology
Volume119
Issue number1
DOIs
StatePublished - Jun 18 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics

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