How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

Stefan Arold*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Focal adhesion kinase (FAK) has an astonishing number of ligands and functions, which enable it to contribute to embryonic development and human health. FAK can promote different effects in similar cellular environments or similar effects in different cellular environments. Recent advances in structural and cellular analysis of FAK are starting to reveal the interrelationships between the conformations, localizations, interactions, and functions of FAK. This review focuses on our emerging understanding of how the structural framework of FAK mechanistically allows it to integrate manifold stimuli into environment-specific functions.

Original languageEnglish (US)
Pages (from-to)808-813
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume21
Issue number6
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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