Host-dependent nitrogen recycling as a mechanism of symbiont control in Aiptasia

Guoxin Cui, Yi Jin Liew, Yi Jin Liew, Yong Li, Yong Li, Najeh M. Kharbatia, Najeh M. Kharbatia, Noura Ibrahim Omar Zahran, Noura Ibrahim Omar Zahran, Abdul-Hamid M. Emwas, Abdul-Hamid M. Emwas, Victor M. Eguiluz, Victor M. Eguiluz, Manuel Aranda, Manuel Aranda

    Research output: Contribution to journalArticlepeer-review

    20 Scopus citations

    Abstract

    The metabolic symbiosis with photosynthetic algae allows corals to thrive in the oligotrophic environments of tropical seas. Different aspects of this relationship have been investigated using the emerging model organism Aiptasia. However, many fundamental questions, such as the nature of the symbiotic relationship and the interactions of nutrients between the partners remain highly debated. Using a meta-analysis approach, we identified a core set of 731 high-confidence symbiosis-associated genes that revealed host-dependent recycling of waste ammonium and amino acid synthesis as central processes in this relationship. Subsequent validation via metabolomic analyses confirmed that symbiont-derived carbon enables host recycling of ammonium into nonessential amino acids. We propose that this provides a regulatory mechanism to control symbiont growth through a carbon-dependent negative feedback of nitrogen availability to the symbiont. The dependence of this mechanism on symbiont-derived carbon highlights the susceptibility of this symbiosis to changes in carbon translocation, as imposed by environmental stress.
    Original languageEnglish (US)
    Pages (from-to)e1008189
    JournalPLOS Genetics
    Volume15
    Issue number6
    DOIs
    StatePublished - Jun 24 2019

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