Histone and chromatin cross-talk

Wolfgang Fischle*, Yanming Wang, C. David Allis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

951 Scopus citations

Abstract

Chromatin is the physiologically relevant substrate for all genetic processes inside the nuclei of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are emerging as key regulators of genomic function. Indeed, a multitude of signals from outside and inside the cell converges on this gigantic signaling platform. Numerous post-translational modifications of histones, the main protein components of chromatin, have been documented and analyzed in detail. These 'marks' appear to crucially mediate the functional activity of the genome in response to upstream signaling pathways. Different layers of cross-talk between several components of this complex regulatory system are emerging, and these epigenetic circuits are the focus of this review.

Original languageEnglish (US)
Pages (from-to)172-183
Number of pages12
JournalCurrent Opinion in Cell Biology
Volume15
Issue number2
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Cell Biology

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