Histidine analogues of oxytocin and vasopressin as efficient ligands for Zn2+ ions - Potentiometric and NMR studies

Justyna Brasuń*, Marek Cebrat, Mariusz Jaremko, Łukasz Jaremko, Olimpa Gładysz, Igor Zhukov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We have characterized the interaction between the Zn2+ ions and the histidine analogues of oxytocin and arginine-vasopressin. Potentiometric methods were used for the determination of the stoichiometry of the complexes formed and the calculation of their stability constants. The NMR measurements revealed detailed structures of the complexes and confirmed the binding mode at physiological pH.

Original languageEnglish (US)
Pages (from-to)1033-1038
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume103
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

Keywords

  • Disulphide bridges
  • Metal ion complexes
  • NMR structure
  • Oxytocin
  • Stability constants
  • Vasopressin
  • Zinc ions

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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