HINT-KB: The human interactome knowledge base

Konstantinos A. Theofilatos, Christos M. Dimitrakopoulos, Dimitrios A. Kleftogiannis, Charalampos N. Moschopoulos, Stergios Papadimitriou, Spiridon D. Likothanassis, Seferina P. Mavroudi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Proteins and their interactions are considered to play a significant role in many cellular processes. The identification of Protein-Protein interactions (PPIs) in human is an open research area. Many Databases, which contain information about experimentally and computationally detected human PPIs as well as their corresponding annotation data, have been developed. However, these databases contain many false positive interactions, are partial and only a few of them incorporate data from various sources. To overcome these limitations, we have developed HINT-KB (http://150.140.142.24:84/Default.aspx) which is a knowledge base that integrates data from various sources, provides a user-friendly interface for their retrieval, estimates a set of features of interest and computes a confidence score for every candidate protein interaction using a modern computational hybrid methodology. © 2012 IFIP International Federation for Information Processing.
Original languageEnglish (US)
Title of host publicationIFIP Advances in Information and Communication Technology
PublisherSpringer Nature
Pages612-621
Number of pages10
ISBN (Print)9783642334115
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Information Systems and Management

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