High-resolution phenotypic profiling of natural products-induced effects on the single-cell level

Stephan Georg Kremb, Christian R. Voolstra

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Natural products (NPs) are highly evolved molecules making them a valuable resource for new therapeutics. Here we demonstrate the usefulness of broad-spectrum phenotypic profiling of NP-induced perturbations on single cells with imaging-based High-Content Screening to inform on physiology, mechanisms-of-actions, and multi-level toxicity. Our technology platform aims at broad applicability using a comprehensive marker panel with standardized settings streamlined towards an easy implementation in laboratories dedicated to natural products research.
Original languageEnglish (US)
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Mar 15 2017

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